法国潜水医学领域继续针对高压氢的抗氧化作用进行研究, 采用8个大气压的氢治疗肝寄生虫曼森血吸虫感染感染引起的肝炎症损伤,仍从抗氧化的角度去分析, 研究表明呼吸一定时间的氢具有抗炎症作用.

到这个时期, 人们考虑到氢的溶解度低,抗氧化需要比较高的分压. 思路上没有什么问题. 而且没有从选择性上考虑问题是非常遗憾的.

Anti-inflammatory properties of molecular
hydrogen: investigation on parasite-induced liver
inflammation
Bouchra Ghariba, Stéphane Hannaa, Ould M.S. Abdallahia, Hubert Lepidib, Bernard Gardettec,
Max De Reggia*
a U399 Inserm, université de la Méditerranée, 27, boulevard Jean-Moulin, 13005 Marseille, France
b Laboratoire d’histologie, université de la Méditerranée, 27, boulevard Jean-Moulin, 13005 Marseille, France
c Comex SA, 36, boulevard des océans,13009 Marseille, France
Received 12 January 2001; accepted 25 April 2001
Communicated by Jean Rosa
Abstract – Molecular hydrogen reacts with the hydroxyl radical, a highly cytotoxic
species produced in inflamed tissues. It has been suggested therefore to use gaseous
hydrogen in a new anti-inflammatory strategy. We tested this idea, with the aid of the
equipment and skills of COMEX SA in Marseille, a group who experiments with
oxygen–hydrogen breathing mixtures for professional deep-sea diving. The model used
was schistosomiasis-associated chronic liver inflammation. Infected animals stayed 2
weeks in an hyperbaric chamber in a normal atmosphere supplemented with 0.7 MPa
hydrogen. The treatment had significant protective effects towards liver injury, namely
decreased fibrosis, improvement of hemodynamics, increased NOSII activity, increased
antioxidant enzyme activity, decreased lipid peroxide levels and decreased circulating
TNF-α levels. Under the same conditions, helium exerted also some protective effects,
indicating that hydroxyl radical scavenging is not the only protective mechanism. These
findings indicate that the proposed anti-inflammatory strategy deserves further attention.
© 2001 Académie des sciences/Éditions scientifiques et médicales Elsevier SAS
inflammation / molecular hydrogen / hydroxyl radical / hyperbaric medicine