The human symbiotic microorganisms (human microbiome) coding the starvation gene (starvatin) and hunger gene (hungerin) and even the materials needs gene (matereedin) for our human beings

Zhang Chenggang*, Gong Wenjing, Li Zhihui, Gao Dawen, Gao Yan

Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Research Center for the Military Cognitive and Mental Health of PLA, Beijing 100850, China

*Correspondence author, ORCID: 0000-0002-4521-3304, E-mail: zhangcg@bmi.ac.cn, Tel: 010-66931590, Address: Taiping Road 27, Beijing, 100850, China.

For a very long time, everyone was told we must eat every day. Yes, it seemed to be an unalterable principle in the human history because if we did not eat food, then the formidable and uncontrolled hunger sensation will cause us die. Many diabetics including myself (CZ) have the experience of despairing and terrible hypoglycemia and it is dangerous in our life. However, in our Chinese old and famous proverb that “chronic diseases come from eating five kinds of grains” (吃五谷得百病), which actually means that if we did not have correct eating style then we will be suffered from a large number of chronic diseases. Therefore, “we have to eat” and “we must eat” have been the golden laws and precious rules in our life almost from the beginning of the human history, until from six years ago to now, we for the first time realized and recognized that it is probably not true because we have preliminarily demonstrated the innovative discovery that the human symbiotic microorganisms (also known as human microbiome) coding the starvation gene (starvatin) and hunger gene (hungerin) and even the materials needs gene (matereedin) for our human beings. In other words, we found that although we human beings in deed did need food to eat every day, however the hungry sensation comes from gut flora but not from our human brain. When the gut flora need carbon sources and nitrogen sources to reproduce their offsprings in our human gut, they will directly send the hungry sensation signals to our body, which will be transferred to our brain by the vagus. Then our brain controls our body to eat to meet the food needed by the gut flora. When the food was intaken after feeding, then most of the nutrition will be absorbed by the small intestine and some others will meet the need by the gut flora. In other words, we everybody need to eat, but the food-eating signals were originated by the gut flora other than our body itself. When we control the food-eating signals for example by using the flexible fasting technologies, then our body can entry the special status like the camels in the desert and can physiologically decompose the glycogen and fat to provide energy for the human body. We can then normally and healthily live for 7-14 days by only feeding the gut flora without food for human body. Only when based on these important facts, can we realize that the starvation gene (starvatin) and the hunger gene (hungerin) of our human beings were actually not coded by the human genes, but by the genes of the human symbiotic microorganisms (human microbiome). Therefore, our new findings will probably modify and update our knowledge on the eating behavior from the bottom level, which means that the textbook will need to be revised in the future. As a large number of chronic diseases were caused by unhealthy eating habits, these chronic diseases will then be controlled by targeting the gut flora based on the new discovery of the gut flora-centric theory. As described in Dickens' famous and classic literary of "A tale of Two Cities", although this is the worst of times, however, the new findings will bring new light to make the era to be the best of times. It is in such a complex, changeable and entangled era, our current works figure out that the symbiotic microbiome coding the starvatin and hungerin and even the matereedin for our human beings. In addition, our further and future works are now focusing on the identification of the spiritual needs genes (spiriteedin) that was coded by the OS/3 (the 3rd operating system, also named as human language and consciousness system), where the symbols, abstraction, logic, and reasoning are the basic coding processing similar as the ACGT base pairs, while the reasoning, thinking and judgment constitute the world of consciousness and spirit. Based on these new explanations of the human body as well as the consciousness coding systems (OS/3), we human beings will have an entirely new understanding of the nature and the world to enjoy the happy life.