The new goal is to reverse aging, not only in animals, but in humans. And age reversal is essential, as significant age-related disruption has already occurred in most people due to changes in our gene expression profiles. In response to these breakthroughs, Life Extension® magazine sent biogerontologist Dr. Gregory M. Fahy to Harvard University to interview Dr. George Church, who is a leading developer of cutting-edge CRISPR techniques. Here, Dr. Church explains remarkable opportunities for transforming human aging that may begin to unfold sooner than most have imagined.
According to legend, the Spanish explorer Ponce de Leon searched Florida for the elusive Fountain of Youth, a source of miraculous water able to cure illness and reverse aging. Although only a myth, researchers have developed a nutritional supplement that may be its real equivalent, capable of reversing aging and preventing and treating devastating diseases such as Alzheimer's and Parkinson's. The supplement, created by scientists at Canada's McMaster University, is a blend of 30 vitamins, minerals and nutrients. All 30 are already available in health food stores and have been safely used by humans for years, some as far back as the ancient Egyptians. "This formula has all the things I have
Researchers at Mayo Clinic have identified the enzyme, called CD38, that is responsible for the decrease in nicotinamide adenine dinucleotide (NAD) during aging, a process that is associated with age-related metabolic decline. Results demonstrated an increase in the presence of CD38 with aging in both mice and humans. The results appear today in Cell Metabolism. "As we age, we experience a decline in our metabolism and metabolic function. This increases the incidence of age-related metabolic diseases like obesity, diabetes and others," says Eduardo Chini, M.D., Ph.D., anesthesiologist and researcher for Mayo Clinic's Robert and Arlene Kogod Center on Aging and lead author of the study. "Previous
