阿尔伯特爱因斯坦医学院（Albert Einstein College of Medicine）的研究人员设计了一种实验药物，可以逆转小鼠阿尔茨海默病的主要症状。这种药物的工作原理是重新激活一种细胞清洁机制（cellular cleaning mechanism）——称为伴侣蛋白介导的自噬（ chaperone-mediated autophagy，CMA），通过消化和再循环去除不需要的蛋白质。这项研究今天在线发表在《细胞》杂志上。

Experimental drug shows potential against Alzheimer's disease

Experimental drug shows potential against Alzheimer's disease: Removing 'garbage' from brain cells improves memory in mice -- ScienceDaily

1. Mathieu Bourdenx, Adrián Martín-Segura, Aurora Scrivo, Jose A. Rodriguez-Navarro, Susmita Kaushik, Inmaculada Tasset, Antonio Diaz, Nadia J. Storm, Qisheng Xin, Yves R. Juste, Erica Stevenson, Enrique Luengo, Cristina C. Clement, Se Joon Choi, Nevan J. Krogan, Eugene V. Mosharov, Laura Santambrogio, Fiona Grueninger, Ludovic Collin, Danielle L. Swaney, David Sulzer, Evripidis Gavathiotis, Ana Maria Cuervo. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell, 2021; DOI: 10.1016/j.cell.2021.03.048