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棕色脂肪细胞燃烧能量,而白脂肪细胞储存能量。超重或肥胖的人往往没有那么多有益的棕色脂肪。一种治疗肥胖症的潜在疗法是移植(人类棕色)脂肪细胞,即用CRISPR基因修饰的人类白脂肪细胞,使之成为类似产生热量的棕色脂肪细胞。
Transplanted brown-fat-like cells hold promise for obesity and diabetes
https://www.sciencedaily.com/releases/2020/08/200826141413.htm
Chih-Hao Wang, et al. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine, Aug 26th, 2020 DOI: 10.1126/scitranslmed.aaz8664
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