赖斯大学（Rice University）显著提高CRISPR基因编辑的准确性。与目前被认为是最先进碱基编辑工具BE4max相比，可以将疾病序列模型中基于CRISPR的编辑精度提高到6000倍。

'Bystander' Cs meet their match in gene-editing technique

https://www.sciencedaily.com/releases/2020/07/200715154244.htm

Sangsin Lee, Ning Ding, Yidi Sun, Tanglong Yuan, Jing Li, Qichen Yuan, Lizhong Liu, Jie Yang, Qian Wang, Anatoly B. Kolomeisky, Isaac B. Hilton, Erwei Zuo, Xue Gao. Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects. Science Advances, 2020; 6 (29): eaba1773 DOI: 10.1126/sciadv.aba1773