绝经前妇女被认为可以免受心血管疾病的影响，但有证据表明肥胖会抵消这些好处，事实上，肥胖会使她们比男性面临更高的风险，但究竟为何如此仍然是一个未解之谜。

研究人员报告说，肥胖女性的性激素孕酮似乎也增加她们患心血管疾病的早期风险。

Why young females with obesity are at early risk for cardiovascular disease

https://www.sciencedaily.com/releases/2019/09/190911142819.htm

Journal Reference:

1. Jessica L. Faulkner, Simone Kennard, Anne-Cecile Huby, Galina Antonova, Qing Lu, Iris Z. Jaffe, Vijay S. Patel, David J.R. Fulton, Eric J. Belin de Chantemèle. Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression. Hypertension, 2019; 74 (3): 678 DOI: 10.1161/HYPERTENSIONAHA.119.12802