研究人员报道了一项新发现的RAS蛋白活性和定位调控机制，RAS蛋白是居于癌症信号传导的中心位置。

New mechanism controlling the master cancer regulator uncovered

https://www.sciencedaily.com/releases/2018/11/181120125849.htm

1. Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory I. Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, André C. Müller, Georg E. Winter, Robert Kralovics, Thijn R. Brummelkamp, Marek Mlodzik, Giulio Superti-Furga. LZTR1 is a regulator of RAS ubiquitination and signaling. Science, 2018; eaap8210 DOI: 10.1126/science.aap8210

======================

明尼苏达大学生物医学工程师的一项新研究报道，即使癌细胞改变运动，如何来阻止癌细胞的移动和扩散。这一发现可能对数百万正在接受治疗以防止癌症在体内传播的人产生重大影响。

'Sneaky' cancer cells stopped in their tracks

https://www.sciencedaily.com/releases/2018/11/181120125824.htm

Erdem D. Tabdanov, Vikram V. Puram, Zaw Win, Ashab Alamgir, Patrick W. Alford, Paolo P. Provenzano. Bimodal sensing of guidance cues in mechanically distinct microenvironments. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-07290-y

==============

研究人员得出结论，应该小心使用抑制表观遗传因素的药物。

Epigenetic treatments could trigger the development of aggressive tumors

https://www.sciencedaily.com/releases/2018/11/181120125914.htm

1. Alexandra Avgustinova, Aikaterini Symeonidi, Andrés Castellanos, Uxue Urdiroz-Urricelqui, Llorenç Solé-Boldo, Mercè Martín, Ivan Pérez-Rodríguez, Neus Prats, Ben Lehner, Fran Supek, Salvador Aznar Benitah. Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours. Nature Cell Biology, 2018; 20 (12): 1400 DOI: 10.1038/s41556-018-0233-x

==================

表观遗传学疗法——靶向改变细胞中什么基因被开启或关闭的酶——作为使癌症不那么具有侵袭性或恶性的一种方法，在癌症领域越来越受到关注。研究人员现在报告说，至少一种最初看起来对肺癌有希望的表观遗传学疗法实际上具有相反的效果，促进被认为能驱动肿瘤的癌症干细胞。

Proposed cancer treatment may boost lung cancer stem cells, study warns

https://www.sciencedaily.com/releases/2018/11/181120073629.htm

1. S. P. Rowbotham, F. Li, A. F. M. Dost, S. M. Louie, B. P. Marsh, P. Pessina, C. R. Anbarasu, C. F. Brainson, S. J. Tuminello, A. Lieberman, S. Ryeom, T. M. Schlaeger, B. J. Aronow, H. Watanabe, K. K. Wong, C. F. Kim. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-07077-1