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科学家们已经发现了对抗耐药细菌的新方法,这种耐药微生物是不断增长的全球威胁。对于导致耐药性的机制知之甚少,这种耐药性策略使细菌对抗生素“无动于衷”,几乎“无法杀死”,从而导致慢性感染极难治疗和治愈。
https://www.sciencedaily.com/releases/2018/09/180913113846.htm
Dorival Martins, Geoffrey McKay, Gowthami Sampathkumar, Malika Khakimova, Ann M. English, Dao Nguyen. Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences, 2018; 201804525 DOI: 10.1073/pnas.1804525115
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