奥托·海因里希·瓦伯格(Otto Heinrich Warburg)提出瓦伯格效应(WarburgEffect),认为癌细胞的生长速度远大于正常细胞的原因来自于能量的来源差别,也就是指肿瘤细胞对糖酵解通路产能依赖增强的现象。癌细胞会偏向使用糖解作用取代一般正常细胞的有氧循环,所以癌细胞使用线粒体的方式与正常细胞就会有所不同。而癌细胞主要使用糖解作用取代有氧循环的现象,就称作瓦伯格效应。
A nine-year joint research project conducted by VIB, KU Leuven and VUB has led to a crucial breakthrough in cancer research. Scientists have clarified how the Warburg effect, a phenomenon in which cancer cells rapidly break down sugars, stimulates tumor growth. This discovery provides evidence for a positive correlation between sugar and cancer,
A nine-year research project looking at the link between sugar and cancer has led to an important breakthrough in cancer research. Credit: qoppi/Shutterstock.com Scientists from The Katholieke Universiteit Leuven in Belgium have revealed how something called the Warburg effect induces tumor growth. The Warburg effect was first observed by Otto Heinrich Warburg in 1924 and refers to the hypothesis that cancer cells break down significantly higher amounts of sugar than healthy cells do. Until now, this effect has been considered a prominent feature of tumor cells, but despite many studies being carried out, researchers have been unable to clarify whether the effect is a cause of cancer or merely