CRISPR编辑鼠基因有助于了解蛇如何失去了腿

CRISPR-Edited Mouse Genes Helps Us Understand How Snakes Lost ...

Science

CRISPR-Edited Mouse Genes Helps Understand How Snakes Lost Their Legs

The disappearance of snakes’ limbs is more than a story of loss-it is a complex history detailed in their DNA. Hoping to understand how and why evolution shaped the snake as it did-and what happened to its genome when it stopped walking-a team of scientists is using the gene-editing CRISPR/Cas9 system to produce the same change in mice. Advances in genetic technology have accelerated the study of evolution via genomics, says Axel Visel, a geneticist at the Lawrence Berkeley National Laboratory. His team hopes to better understand the evolution of morphology, or the way animals physically look. “We decided to look at one of the most dramatic morphological adaptations that happened in vertebrate

Scientific American

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