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Researchers develop new ligase for biomedical …
Researchers Develop New Ligase for Biomedical …
Brown University researchers develop new ligase …
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Biomedical researchers develop new RNA ligase for laboratory use
Ligases are enzymes that serve critical functions in cells, helping to fuse together broken strands of DNA and RNA. These enzymes are also important bioengineering tools, useful in genetic sequencing, mutation detection and other applications. Researchers in Brown University's School of Engineering have now developed a new RNA ligase for laboratory use. Derived from a microbe that thrives near volcanic thermal vents, the new ligase, called KOD1Rnl, can work at the high temperature desirable for some laboratory procedures. It's also the most active in the presence of certain RNA structures, called templates, which makes it useful for RNA sequencing and detection. "This new ligase has all the properties
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