全心全意行,平平常常心分享 http://blog.sciencenet.cn/u/sunx0053 美国明尼苏达大学药学系,副教授

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用共晶改进药品的压片性能

已有 4441 次阅读 2009-12-1 13:14 |个人分类:科研成果|系统分类:论文交流| 制药, 孙常全, 晶体工程, 压片, 孙常全

晶体工程是我科研的方向之一。  我会陆续把一些有代表性的文章在此平台发出。  希望有共同兴趣的学者多交流和提意见。

By the formation of a 1:1 cocrystal of caffeine and methyl gallate, we demonstrated that powder compaction properties could be profoundly improved. The selection criterion for cocrystal exhibiting superior compaction properties was the presence of slip planes in crystal structure. Bulk cocrystal was prepared by suspending powders of the two pure compounds in ethanol. Fine powders of similar particle size distribution were compressed. Within the whole range of compaction pressure, the tablet tensile strength of methyl gallate was very poor (<0.5 MPa) and severe lamination and sticking occurred in almost all tablets. Tabletability of caffeine was acceptable at <150 MPa. However, at >180 MPa, severe lamination of caffeine tablets suddenly occurred. Tablet tensile strength dropped sharply at >240 MPa. In contrast, the tabletability of the cocrystal was excellent over the entire pressure range. Tablet tensile strength of the cocrystal was ∼2 times that of caffeine at <200 MPa, and the ratio gradually increased with increasing pressure, e.g., ∼8 fold at 350 MPa. Poor tablet tensile strength was always associated with high elastic recovery and low plasticity. The good plasticity and tabletability of the cocrystal validated the selection criterion, i.e., the presence of slip planes in crystal structure.

晶体工程

https://blog.sciencenet.cn/blog-356017-275314.html


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