Volume 2  Issue 3

封 面 解 读

张子杰

A girl stands firm upon a majestic dragon boat, the embodiment of ancient Chinese culture and resilience, with an outsized syringe, a symbol of novel vaccines technologies. The girl battles a tempest of COVID-19 virus that has loomed over the world, using biotechnology. Scientists relentlessly navigate the stormy seas of infectious diseases, which signifies not only the ongoing efforts to combat the current pandemic but also the broader commitment to safeguarding public health through science and innovation. Yu and his colleagues presented a randomized clinical trial of omicron XBB.1.5-containing bivalent COVID-19 mRNA vaccine in head-to-head comparison with other two mRNA vaccines encoding earlier variants, clarifying that newer variant-matched vaccine elicits an enhanced immune response against newly emerged variants. As we navigate through intricate molecular landscapes, vaccines herald a new frontier in our enduring battle against existing and newly emerged pathogens, promising a future where health prevails.

目     录

导     读

1.Medicine has no borders, health unites us all: Henry Norman Bethune as a pioneer, medical scientist, and internationalist

hLife | 健康无国界，医者共仁心: 白求恩——一位伟大的医学先驱，医术精湛的医生，英勇的国际主义战士

通讯作者: 刘欢

文章介绍了医术精湛的医生、国际主义战士亨利·诺尔曼·白求恩（Henry Norman Bethune）。

引用：

Liu H, Gong X, Liu Z, et al. Medicine has no borders, health unites us all: Henry Norman Bethune as a pioneer, medical scientist, andinternationalist. hLife 2024;2:97–99.

doi: https://doi.org/10.1016/j.hlife.2023.11.002

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2. Phenazines: Natural products for microbial growth control

通讯作者: Manuel Simões

Highlights

•Phenazines are essential for iron acquisition, signalling and biofilm formation.

•Phenazines are recognized as an important source for antimicrobial drug development.

•Phenazine-inspired antibiotics are very active against resistant bacteria.

•Phenazine-based antibiotics are effective against methicillin-resistant Staphylococcus aureu (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and ancomycin-resistant Enterococcus faecium (VRE).

引用：

Sousa CA, Ribeiro M, Vale F, et al. Phenazines: Natural products for microbial growth control. hLife 2024;2:100–112.

https://doi.org/10.1016/j.hlife.2023.11.005

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3.Safety, immunogenicity, and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containing bivalent mRNA vaccine

通讯作者：周太成，游顶云，韦嘉，张子杰 

Highlights

•XBB.1.5-containing bivalent generated superior immunogenicity against XBB lineages compared to BA.2/BA.5-containing bivalent.

•The efficacy of booster dose against XBB lineages waned after 2-3 months.

•Newer variant-matched vaccine elicits an enhanced immune response against newly emerged variants.

引用：

Yu X, Yang W, Li W, et al. Safety, immunogenicity, and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containingbivalent mRNA vaccine. hLife 2024;2:113–125.

https://doi.org/10.1016/j.hlife.2024.01.005

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4. A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants by targeting the upstream region of spike protein HR2 motif

通讯作者：王岚峰, 林正红，张素平

Highlights

•A newly isolated human neutralizing monoclonal antibody 39 (mAb-39) can neutralize SARS-CoV-2 and its variants.

•mAb-39 improves the activity of anti-receptor-binding domain (anti-RBD) antibody against Omicron variants.

•mAb-39 binds to a conserved epitope within the upstream region of the heptad repeat 2 (HR2) motif of Omicron spike protein.

•Point mutation within the upstream region of HR2 reduces the capacity of spike protein-induced membrane fusion.

引用：

Su H, Zhang J, Yi Z, et al. A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants by targeting the upstream regionof spike protein HR2 motif. hLife 2024;2:126–140.

doi: https://doi.org/10.1016/j.hlife.2024.02.001

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5. The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses

hLife Letter | HSV-1 gB-中和抗体复合物结构揭示疱疹病毒潜在广谱中和结构域

通讯作者：孙聪，刘铮，曾木圣 

本研究首次解析单纯疱疹病毒1型（HSV-1）gB与中和抗体复合物结构，提示疱疹病毒gB的DII结构域存在序列和结构上高度保守的抗原表位，为疱疹病毒广谱药物和疫苗研发提供重要的靶标。

引用：

Sun C, Yang J, Xie C, et al. The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenicdomain across herpesviruses. hLife 2024;2:141–146. 

doi: https://doi.org/10.1016/j.hlife.2023.12.004

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hLife官方网址：https://www.sciencedirect.com/journal/hlife