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MCE 国际站:Dostarlimab
CAS:2022215-59-2
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Dostarlimab (TSR-042) 是一种人源化抗 PD-1 单克隆抗体。Dostarlimab 与人 PD-1 具有高亲和力,并竞争性地抑制其与其配体 PD-L1 和 PD-L2 的相互作用,IC50s 分别为 1.8 nM 和 1.5 nM。
体外:Dostarlimab (10-10000 ng/mL) 以剂量依赖的方式与人和食蟹猴 CD3+ T 细胞上表达的原生 PD-1 受体结合[1]。 Dostarlimab (0-375 nM; 48 h) 在人 CD4+ T 细胞 MLR 实验中增加 IL-2 的产生,EC50 大约为 1 nM,在葡萄球菌肠毒素 B (SEB) 刺激的 PBMC 细胞中增加 IL-2 的产生,EC50 大约为 0.1 nM,增强干扰素 (IFN)-γ 的释放,EC50 大约为 0.5 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Dostarlimab (200 µg/mouse; i.p.; twice weekly for 35 days) 在人源化小鼠模型中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Humanized NOG-EXL mice, A549 and MDA-MB-436 tumor model[1] Dosage: 200 µg/mouse Administration: Intraperitoneal injection; twice weekly for 35 days Result: Resulted in great inhibition of tumor growth in an A549 lung cancer model (tumor growth inhibition [TGI] of 62% at termination). The antitumor activity was associated with a reduction in tumor-associated regulatory T cells and a trend toward increased tumor-infiltrating CD8+ T cells. Inhibited tumor growth of MDA-MB-436 breast cancer model (TGI of 53%). Clinical Trial
热销产品:R-spondin 3, Human (125aa, HEK293, His) | Trigonelline | Triciribine | Codrituzumab | Coenzyme Q9 | Fosmidomycin sodium salt | WSP-1 | Stearoylcarnitine | LEP(116-130)(mouse) | Prazosin (hydrochloride)
作用靶点:PD-1/PD-L1
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Kumar S, et al. Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models. MAbs. 2021 Jan-Dec;13(1):1954136.
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