Leucomethylene blue (mesylate)

MCE 国际站：Leucomethylene blue (mesylate)

CAS：1236208-20-0

品牌：MedChemExpress (MCE)

存储条件：4°C, stored under nitrogen, away from moisture

生物活性：Leucomethylene blue (TRx0237) mesylate 是一种具有口服活性的第二代 tau 蛋白聚集抑制剂（K_i 为 0.12 μM），可用于阿尔茨海默病的研究。甲磺酸无色亚甲蓝是亚甲蓝的常见还原形式，亚甲蓝是噻嗪类染料的成员^{[1][2][3]。 IC50 和目标：Ki：0.12 μM (tau)[3]。}

体外：Leucomethylene blue (100 nM, 48 h) mesylate 不仅降低了 tau 和 p-tau 的表达水平，而且逆转了 Aβ25-35 对食欲素 A 和腺苷 A1R 表达水平的促进作用^[2] .

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研究领域：Neuronal Signaling

作用靶点：Amyloid-β

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参考文献：[1]. Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33.

[2]. Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. Int J Mol Med. 2019 Jan;43(1):435-442.

[3]. Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother. 2016;17(4):457-61.