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Naloxonazine (dihydrochloride)
MCE 国际站:Naloxonazine (dihydrochloride)
CAS:880759-65-9
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Naloxonazine dihydrochloride 是一种特异性 μ-opioid receptor 拮抗剂,IC50 为 5.4 nM。 Naloxonazine dihydrochloride 还具有抗利什曼原虫活性[1][2][3]。
体外:Naloxonazine 在溶液中相对稳定[2]。Naloxonazine (72 h) 对 Leishmania donovani 细胞内无鞭毛体阶段有活性,半数最大抑制浓度 ( GI50) 为 3.45 μM[3]。纳洛嗪(10 μM;0-72 小时)在杜氏利什曼原虫<的早期阶段具有活性/i> 感染[3]。纳洛嗪影响宿主细胞的酸性区室,进而限制L。 donovani 细胞内生长[3]。
体内:Naloxonazine(20 mg/kg;ip;一次)减弱小鼠急性甲基苯丙胺诱导的运动活动增加[1]
热销产品:Navoximod | TLR7/8 agonist 1 | Tolebrutinib | Ricolinostat | Valsartan | Novobiocin (sodium) | Bixin | Pilocarpine | Cinnabarinic acid | Kanamycin (sulfate)
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Opioid Receptor
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Chien CC, et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212(1):61-5.
[2]. Hahn EF, et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31(12-13):1385-8.
[3]. De Muylder G, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234.
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