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MCE 国际站:Erasin
品牌:MedChemExpress (MCE)
存储条件:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
生物活性:Erasin 是一种有效的 Erlotinib (HY-50896) 抗性 STAT3 抑制剂,对 STAT3 和 STAT1 的 IC50 分别为 9.7 和 24 μM。Erasin 诱导癌细胞凋亡(apoptosis)。
体外:Erasin 抑制 STAT SH2 结构域介导的蛋白-蛋白相互作用[1]。 Erasin (0-80 μM;24 h) 诱导 MDA-MB-231、HCC-827 和 Erlotinib (HY-50896) 耐药 HCC-827 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
热销产品:ACEA | Quercetagetin | Piroxicam | Calmidazolium (chloride) | PHA-793887 | GS-441524 | SMER28 | CCT369260 | TDI-11861 | Methyltetrazine-PEG5-methyltetrazine
研究领域:JAK/STAT Signaling | Stem Cell/Wnt | Apoptosis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Lis C, et al. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Sci Rep. 2017 Dec 12;7(1):17390.
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