Erasin

MCE 国际站：Erasin

品牌：MedChemExpress (MCE)

存储条件：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

生物活性：Erasin 是一种有效的 Erlotinib (HY-50896) 抗性 STAT3 抑制剂，对 STAT3 和 STAT1 的 IC50 分别为 9.7 和 24 μM。Erasin 诱导癌细胞凋亡(apoptosis)。

体外：Erasin 抑制 STAT SH2 结构域介导的蛋白-蛋白相互作用[1]。 Erasin (0-80 μM;24 h) 诱导 MDA-MB-231、HCC-827 和 Erlotinib (HY-50896) 耐药 HCC-827 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：STAT  |  Apoptosis

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Lis C, et al. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Sci Rep. 2017 Dec 12;7(1):17390.