Citalopram | 西酞普兰

MCE 国际站：Citalopram

中文名：西酞普兰

CAS：59729-33-8

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：西酞普兰作为 S(+)-对映体和 R(-)-对映体以及具有抑制作用的活性 S(+)-对映体 (依他普仑) 的外消旋混合物销售。西酞普兰是一种抗抑郁药，可通过有效和选择性地抑制 5-羟色胺再摄取（选择性 5-羟色胺再摄取抑制剂）来增强 5-羟色胺能神经传递^[1][2]。

体外：Citalopram (25-175 μM；24 小时) 显示出浓度依赖性细胞毒性[3]。 Citalopram (100 μM；24 小时) 强烈下调 B104 细胞中的 MYBL2、BIRC5、BARD1、AURKA、CCNA2 和 CCNE1[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Citalopram (5-40mg/kg；腹腔注射) 可减少 DBA/2J 小鼠的不动时间，但不会减少 C57BL/6J 小鼠[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J and DBA/2J mice, aged 5-7 weeks, 16-20 g[4] Dosage: 5-40 mg/kg Administration: IP Result: Reduced immobility time in DBA/2J mice but not in C57BL/6J mice. Clinical Trial

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研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

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参考文献：[1]. Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76.

 [2]. Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477. 

[3]. Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.

[4]. Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631.