Cortisone | 可的松

MCE 国际站：Cortisone

中文名：可的松

CAS：53-06-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：可的松 (17-Hydroxy-11-dehydrocorticosterone)，皮质醇（一种糖皮质激素）的氧化代谢物。可的松用作免疫抑制剂和抗炎剂。高浓度可的松可部分干预糖皮质激素与糖皮质激素受体的结合^{[1][3][4]。 IC50 和目标：糖皮质激素受体[1]}  

体外：可的松 (2.8-28,000 nM) 以剂量依赖性方式减弱外周血单核细胞 (PBMC) 中皮质醇诱导的细胞凋亡^[1]。

体内：可的松（2 mg/kg；隔日肌注，持续 2 个月）减少兔的 BCG（结核杆菌疫苗株）损伤和结核菌素反应^[2]。

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研究领域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor  |  Metabolic Enzyme/Protease

作用靶点：Glucocorticoid Receptor  |  Endogenous Metabolite

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1(12):2109-15.

[2]. McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3(2):159-76.

[3]. Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41(8):1299-1302.

[4]. Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115(5):1370-4.