CD1530

MCE 国际站：CD1530

CAS：107430-66-0

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：CD1530 是一种选择性 RARγ 激动剂，K_d 为 150 nM^[1]。在人类口腔和食管鳞状细胞癌小鼠模型中，CD1530 与贝沙罗汀联合使用可抑制致癌物 4-硝基喹啉 1-氧化物诱导的口腔癌发生^[2]。

热销产品：BIM-23056  | Glycitin  | Lipoprotein lipase  | Wu-5  | α-Arbutin  | Ras Antibody  | Nagilactone B  | H3K4(Me3) (1-20)  | Phosphoglycerate kinase  | CREBtide

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：RAR/RXR

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Bernard BA, et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.

[2]. Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.