Aripiprazole | 阿立哌唑

MCE 国际站：Aripiprazole

中文名：阿立哌唑

CAS：129722-12-9

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：Aripiprazole (OPC-14597) 是一种非典型抗精神病药，是一种有效且高亲和力的 dopamine D2 receptor 部分激动剂。 Aripiprazole 是 5-HT2B 和 5-HT2A 受体的反向激动剂，对 5-HT1A、5- HT2C、D3 和 D4 受体。阿立哌唑可用于精神分裂症和COVID19的研究^[1][2][3][4]。  

体外：阿立哌唑有效激活 D2 受体介导的 cAMP 积累抑制^[1]。阿立哌唑对 TNF-α、IL-13、IL-17α 和 fractalkine 显示出更强的抗炎作用^[3]。

体内：Aripiprazole（0-3 mg/kg，IP，每日）表现出一定的抗焦虑特性^[4]。

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研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Dopamine Receptor

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Stip E, et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

[2]. Burris KD, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.

[3]. Davies MA, et al. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 Winter;10(4):317-36.

[4]. Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2;12:646701.

[5]. Russo E, et al. Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. Neuropharmacology. 2013 Jan;64:371-9.