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MCE 国际站:Muscone
中文名:麝香酮
CAS:541-91-3
品牌:MedChemExpress (MCE)
存储条件:Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:麝香酮是中药麝香的主要活性单体。 Muscone 抑制NF-κB 和NLRP3 炎性体激活。麝香酮显着降低炎症细胞因子(IL-1β、TNF-α 和IL-6)的水平,并最终改善心脏功能和生存率[1]。
体外:Muscone 显着下调 LPS 诱导的炎性细胞因子水平,并抑制骨髓来源的巨噬细胞 (BMDM) 中的 NF-κB 和 NLRP3 炎性体激活。 Muscone 是一种很有前途的有效药物,可用于治疗心肌梗死 (MI) 后[1]。
热销产品:ERK1/2 Antibody | DN02 | Eltrombopag (Olamine) | Nuezhenidic acid | Daidzin | Clotrimazole | Pindolol | CP26 | Dabigatran | RK-287107
研究领域:Immunology/Inflammation | Apoptosis | NF-κB
作用靶点:Interleukin Related | TNF Receptor | NF-κB | NOD-like Receptor (NLR)
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Du Y, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018 Dec 15;10(12):4235-4246.
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