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MCE 国际站:Amentoflavone
中文名:穗花杉双黄酮
CAS:1617-53-4
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Amentoflavone (Didemethyl-ginkgetin) 是一种有效的口服活性 GABA(A) 负调节剂。 Amentoflavone 还显示出抗炎、抗氧化、抗病毒、抗肿瘤、抗辐射、抗真菌、抗菌活性。 Amentoflavone 在亚 G1 期诱导细胞凋亡和细胞周期停滞[1][2][3] [4]。
体外:Amentoflavone (1-60 µM) 在 RAW 264.7 细胞中以浓度依赖性方式抑制一氧化氮的产生[2]。Amentoflavone (50-200 µM) 抑制 U 的活力-87 MG 细胞,48 小时时 IC50 值为 100 µM[3]。Amentoflavone(0、50、100 µM;48 小时)诱导细胞凋亡和细胞周期停滞在亚 G1 期[3]。Amentoflavone(0、50、100 µM;48 小时)抑制 NF-ĸB 激活并降低 MCL1 和 C- 的表达U-87 MG 细胞中的 FLIP 蛋白[3].Amentoflavone (0-32 µg/ml) 具有抗菌活性,MIC 为 8、4、32、8、16、8 µg /ml 用于 E。屎 ATCC 19434, S.金黄色葡萄球菌 ATCC 25923, S.变形杆菌 ATCC 3065, E.大肠杆菌 O-157 ATCC 25922, E.大肠杆菌 ATCC 43895, P. aeruginosa ATCC 27853,分别为[4]。
体内:Amentoflavone(25 mg/kg;口服;每天一次,连续 3 天)在小鼠中通过抗炎作用显示出对癫痫的神经保护作用[1]。
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研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis | Anti-infection | Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:Reactive Oxygen Species | Apoptosis | Bacterial | Fungal | RSV | GABA Receptor
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10(7):1125-33.
[2]. Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51(6):539-46.
[3]. Yen TH, et al. Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells. In Vivo. 2018 Mar-Apr;32(2):279-285.
[4]. Hwang JH, et al. Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23(7):953-8.
[5]. Hanrahan JR, et al. Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.
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