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(S,R,S)-AHPC-Me (hydrochloride)
MCE 国际站:(S,R,S)-AHPC-Me (hydrochloride)
CAS:1948273-03-7
品牌:MedChemExpress (MCE)
存储条件:-20°C, sealed storage, away from moisture
生物活性:(S,R,S)-AHPC-Me hydrochloride(VHL 配体 2 盐酸盐)是基于 (S,R,S)-AHPC 的 VHL 配体,用于募集 von Hippel-Lindau (VHL) 蛋白 [1]. (S,R,S)-AHPC-Me hydrochloride 可用于合成 ARV-771,这是一种基于 von Hippel-Landau (VHL) E3 连接酶的 BET PROTAC 降解剂。 ARV-771 可有效降解去势抵抗性前列腺癌 (CRPC) 细胞中的 BET 蛋白,DC50 <1 nM[2]。 IC50 和目标:E3 连接酶的配体[1]
热销产品:Furafylline | Capecitabine | 25-Hydroxycholesterol | Angiotensin II human (acetate) | Linezolid | Amiloride (hydrochloride) | β-Amanitin | L-Tryptophan | ARV-771 | γ-Aminobutyric acid
研究领域:PROTAC
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. WO/2017/030814A1
[2]. Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.
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