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Codrituzumab 是一种靶向GPC3 (glypican-3) 的单克隆抗体 |MedChemExpress
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MCE 国际站：Codrituzumab
CAS：1365267-33-9
品牌：MedChemExpress (MCE)
存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性：Codrituzumab 是一种靶向GPC3 (glypican-3) 的单克隆抗体。 GPC3 是一种在肝细胞癌 (HCC) 细胞表面表达的癌胚蛋白。 Codrituzumab 诱导抗体依赖性细胞毒性 (ADCC) 并抑制肿瘤生长[1][2]。
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研究领域：Others
作用靶点：Others
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参考文献：[1]. Mika Endo, et al. Abstract 2747: Anti-glypican-3 monoclonal antibody (codrituzumab/GC33/RO5137382) treatment enhances tumor infiltration of PD-L1-positive macrophages, and combination therapy with anti-PD-L1 monoclonal antibody promotes antitumor effects. Cancer Res (2018) 78 (13_Supplement): 2747.
[2]. Chen G, et al. Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget. 2018 Jan 2;9(12):10436-10444.
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