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(20R)-Ginsenoside Rg3 | (20R)-人参皂苷Rg3
MCE 国际站:(20R)-Ginsenoside Rg3
中文名:(20R)-人参皂苷Rg3
CAS:38243-03-7
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性: (20R)-ginsenoside Rg3 ((20R)-Propanaxadiol),人参根中存在的活性化合物之一,可抑制血管内皮生长因子 (VEGF)(IC 50=10 nM) 和抗肿瘤活性[1][2]。
体外:(20R)-ginsenoside Rg3 抑制人脐静脉内皮细胞 (HUVEC) 增殖,IC50 为 10 nM[1]。 无论存在或不存在 20 ng/mL VEGF,(20R)-ginsenoside Rg3 也会剂量依赖性地抑制基质胶上 HUVEC 毛细管的形成[1]。 在大鼠主动脉环实验中,(20R)-ginsenoside Rg3 显着减弱 VEGF 诱导的 HUVEC 化学侵袭和离体微血管萌芽[1]。 在体内基质胶塞测定中(20R)-ginsenoside Rg3 (150 和 600 nM)显着消除碱性成纤维细胞生长因子 (bFGF) 诱导的血管生成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:(20R)-ginsenoside Rg3 (0.05-0.5 mg/kg;鼻内给药;持续 2 周)通过鼻内给药在小鼠中显示出抗疲劳作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Kunming mice weighing 18-22 g[2] Dosage: 0.05 mg/kg, 0.1 mg/kg, 0.5 mg/kg (5 μL each nostril) Administration: Intranasal administration; for 2 weeks Result: Significantly prolonged the weight-loaded swimming time, and also increased the hepatic glycogen levels.
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研究领域:Others
作用靶点:Others
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参考文献:[1]. Yue PY, et al. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45.
[2]. Wenyan Tang, et al. The anti-fatigue effect of 20(R)-ginsenoside Rg3 in mice by intranasally administration. Biol Pharm Bull. 2008 Nov;31(11):2024-7.
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