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MCE 国际站:Argipressin
中文名:精氨加压素
CAS:113-79-1
品牌:MedChemExpress (MCE)
存储条件:Powder: -80°C, 2 years; -20°C, 1 year.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Argipressin (Arg8-vasopressin) 与V1、V2、V3-血管精氨酸加压素受体结合,Kd 值为 1.31 nM A7r5大鼠主动脉平滑肌细胞为V1。
体外:Argipressin 与血管精氨酸加压素受体 V1 结合,在 A7r5 大鼠主动脉平滑肌细胞中的 Kd 值为 1.31 nM。它还刺激 A7r5 细胞中钙的细胞内释放 (EC50=5 nM)[1]。 AVP 诱导的 [Ca2+]i 信号和针对 DRG 细胞培养物中 S-100 的免疫活性。在 DRG 培养的非神经元细胞中,Argipressin 引起 [Ca2+]i 反应的最低有效浓度为 100 pM[2]。
热销产品:Sulforaphane | Infliximab | Nicotinamide | Carboplatin | AP20187 | Vancomycin (hydrochloride) | Urelumab | CCCP | Calcitriol | Simvastatin
研究领域:GPCR/G Protein
作用靶点:Vasopressin Receptor
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.
[2]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.
[3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257.
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