Prednisolone | 泼尼松龙

MCE 国际站：Prednisolone

中文名：泼尼松龙

CAS：50-24-8

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：泼尼松龙是一种有效的口服活性皮质类固醇和糖皮质激素。泼尼松龙的抗炎活性是氢化可的松的四倍左右，同时减少盐和水潴留。泼尼松龙可用于眼部、抗炎研究^[1][2]。

体外：泼尼松龙（0.002-10 μg/mL；3 天）抑制人白细胞有丝分裂^[4]。

体内：泼尼松龙（5 毫克/千克/天；口服；每周 6 天，持续 72 周）显着预防小鼠因肾病死亡^[3]。

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研究领域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor  |  Metabolic Enzyme/Protease

作用靶点：Glucocorticoid Receptor  |  Endogenous Metabolite

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参考文献：[1]. Prednisolone. J Am Pharm Assoc. 1976;16(3):143-146.

[2]. Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102.

[3]. Hahn B H, et al. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in nzp/nzw mice. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 1973, 16(2): 163-170.

[4]. NOWELL PC. Inhibition of human leukocyte mitosis by prednisolone in vitro. Cancer Res. 1961 Dec;21:1518-21.