|
MCE 国际站:Bongkrekic acid
CAS:11076-19-0
品牌:MedChemExpress (MCE)
存储条件:Pure form: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Bongkrekic acid 是一种线粒体毒素,由细菌 Pseudomonas cocovenenans[1] 分泌。线粒体腺嘌呤核苷酸转位酶 (ANT) 而非电子传递链的 Bongkrekic 酸特异性配体。 Bongkrekic acid 必须穿过线粒体内膜才能产生对 ADP/ATP 转运的抑制作用[2]。
体外:Bongkrekic acid(0-50 μM;48 小时)刺激 MDA-MB-231、MCF-7 和 LTED 细胞中的甲臜形成,EC50 分别为 34.14 μM、>50 μM 和 2.58 μM。Bongkrekic acid (0.1-25 μM; 48 hours) 以剂量依赖性方式降低 LTED 细胞和母体 MCF-7 细胞中的活细胞数量[1]。
热销产品:KNT-127 | Insulin-Transferrin-Selenium, 100X | Vinpocetine | Cytosine | Nicardipine (hydrochloride) | Kinetin | Pyrithioxin (dihydrochloride) | Omecamtiv mecarbil | EB-3D | Drinabant
研究领域:Membrane Transporter/Ion Channel
作用靶点:ATP Synthase
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Mehruba Anwar, et al. Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin. J Med Toxicol. 2017 Jun;13(2):173-179.
[2]. C Dahout-Gonzalez, et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda)
[3]. Shuso Takeda, et al. Bongkrekic Acid as a Warburg Effect Modulator in Long-term Estradiol-deprived MCF-7 Breast Cancer Cells. Anticancer Res
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-8-15 06:24
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社