1-Deoxynojirimycin | 1-脱氧野尻霉素

MCE 国际站：1-Deoxynojirimycin

中文名：1-脱氧野尻霉素

CAS：19130-96-2

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：1-Deoxynojirimycin (Duvoglustat) 是一种有效的口服活性 α-葡萄糖苷酶 抑制剂。 1-Deoxynojirimycin 可抑制餐后血糖，广泛用于糖尿病。 1-Deoxynojirimycin 具有抗高血糖、抗肥胖和抗病毒作用^[1][2]。 

体内：1-Deoxynojirimycin (Duvoglustat)（20-80 mg/kg；iv；每日一次，持续 4 周）显示抗肥胖作用^[3]。1-Deoxynojirimycin 通过激活显着改善胰岛素敏感性db/db小鼠骨骼肌胰岛素信号通路PI3K/AKT^[3]。

热销产品：9-Aminocamptothecin  | SJB2-043  | Lemzoparlimab  | [D-p-Cl-Phe6,Leu17]-VIP (TFA)  | Apratastat  | Norwogonin  | Malate dehydrogenase  | GSK-J2  | L-Alpha-Lysophosphatidylcholine,oleoyl-d7  | Saikosaponin B2

研究领域：Metabolic Enzyme/Protease  |  PI3K/Akt/mTOR

作用靶点：Glucosidase  |  PI3K

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232

[2]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.

[3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.