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L-Palmitoylcarnitine (chloride)
MCE 国际站:L-Palmitoylcarnitine (chloride)
CAS:18877-64-0
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:L-Palmitoylcarnitine chloride 是一种长链酰基肉碱和一种脂肪酸代谢物,在肌膜中积聚并在缺血期间扰乱膜脂质环境。 L-Palmitoylcarnitine chloride 通过与 Kir6.2 的相互作用抑制 KATP 通道 活性,而不影响单通道电导[1] 。
体外:L-Palmitoylcarnitine (1 µM) 通过与 Kir6.2 的相互作用抑制 KATP 通道活性,而不影响单通道电导。 L-棕榈酰肉碱同时增强通道的 ATP 敏感性(IC50 从 62 降至 30 µM)[1]。膜脂环境的调节导致L-棕榈酰肉碱主要通过与内源性 PI 级联反应,尤其是 PIP2[1] 的相互作用改变 KATP 通道功能。
热销产品:DOTA-tri(t-butyl ester) | Tranexamic acid | AMTB (hydrochloride) | 8-Hydroxy-2'-deoxyguanosine | Methylprednisolone succinate (sodium) | CH6953755 | Biotin-HPDP | Pyridoxal phosphate | Herbacetin | SMIP004
研究领域:Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点:Potassium Channel | Endogenous Metabolite
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.
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