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Tin protoporphyrin IX dichloride | 锡原卟啉IX
MCE 国际站:Tin protoporphyrin IX dichloride
中文名:锡原卟啉IX
CAS:14325-05-4
品牌:MedChemExpress (MCE)
存储条件:-20°C, sealed storage, away from moisture
生物活性:锡原卟啉 IX (SnPPIX) 是一种有效的血红素加氧酶-1 (HO-1) 抑制剂。在小鼠模型中,锡原卟啉 IX (SnPPIX) 使胰腺导管腺癌 (PDAC) 肿瘤对化疗敏感[1]。 IC50 和目标:IC50:血红素加氧酶-1 (HO-1)[1]
体外:锡原卟啉 IX (SnPPIX)(20 μM,50 μM;24 小时)显着抑制 Capan-1 和 CD18/HPAF 细胞的增殖。相反,SnPPIX 在除 50 μM[1] 外的所有暴露条件下均对 PDAC 细胞增殖没有显着影响。
体内:锡原卟啉 IX (SnPPIX)(腹腔注射;5 mg/kg;第 0、7、15 和 20 天)单独或与吉西他滨联用显着减轻胰腺肿瘤重量(P < 0.05),减少转移并改善吉西他滨治疗的疗效[1].
热销产品:CD1530 | GW 441756 | Nelarabine | Nitro blue tetrazolium chloride | Oseltamivir | Dracorhodin perchlorate | Fluvastatin (sodium) | Istaroxime (hydrochloride) | Methylprednisolone succinate | Canagliflozin (hemihydrate)
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.
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