Iohexol | 碘海醇

MCE 国际站：Iohexol

中文名：碘海醇

CAS：66108-95-0

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：碘海醇是一种射线照相造影剂，可用于脊髓造影、计算机断层扫描？（脑池造影、脑室造影）和显微 CT 成像体内^[1] .

体外：Iohexol (150 mg I/mL, 0-24 h) 抑制 NRK 52-E 的细胞活力[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Iohexol (0.25-4 mL/kg, p.o., weekly) 浓度为 0.5-2.0 mL/kg 时，可促进狗肠段的分化[4]。 Iohexol (64.7 mg/kg，静脉注射) 可用于估算健康或患有慢性肾病 (CKD) 的犬的肾小球滤过率 (GFR)[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Healthy dogs [4] Dosage: 0.25-4 mL/kg Administration: Oral gavage (p.o.), weekly Result: Peaked the iohexol serum concentrations between 2 and 4 hours. Reduced radiolucency after application of 0.25 mL/kg and 4 mL/kg. Included watery diarrhea after ingestion of 4 mL/kg. Clinical Trial

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研究领域：Autophagy

作用靶点：Autophagy  |  Mitophagy

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参考文献：[1]. Hainfeld JF, Ridwan SM, Stanishevskiy Y, Smilowitz NR, Davis J, Smilowitz HM. Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging. Sci Rep. 2018 Sep 14;8(1):13803.

[2]. Soman RS, et al. Development and validation of an HPLC-UV method for determination of iohexol in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):339-43.

 [3]. Jensen H, et al. The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E. Ren Fail. 2011;33(4):426-33.

 [4]. Klenner S, et al. Estimation of intestinal permeability in healthy dogs using the contrast medium iohexol. Vet Clin Pathol. 2009 Sep;38(3):353-60.

[5]. Baklouti S, et al. Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Front Pharmacol. 2021 Apr 29;12:634404.