Allopurinol | 别嘌醇

MCE 国际站：Allopurinol

中文名：别嘌醇

CAS：315-30-0

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Allopurinol 是一种有效的口服活性黄嘌呤氧化酶抑制剂，IC₅₀ 值为 0.2-50 μM。别嘌醇可用于治疗高尿酸血症和痛风。 Allopurinol 降低 HIF-1α 和 HIF-2α 蛋白的表达。 Allopurinol 具有抗抑郁和抗伤害活性。抗利什曼病作用^{[1][2][3][4][5]} 。  

体外：Allopurinol (0, 10, 100, 1000 µg/ml; 17 h) 降低HFF和HUVEC细胞中HIF-1α和HIF-2α蛋白的表达^[5].Allopurinol ( 0, 10, 100, 1000 µg/ml; 24 h) 降低 HUVEC 细胞的血管生成特性^[5]。

体内：别嘌醇（39 毫克/千克；口服；每日一次，连续 21 天）在小鼠体内显示出抗抑郁活性^[3]。别嘌醇（10-400 毫克/千克；腹腔注射）诱导抗抑郁- 小鼠的伤害感受活动^[4]。

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研究领域：Metabolic Enzyme/Protease

作用靶点：Xanthine Oxidase

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参考文献：[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

[2]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.

 [3]. Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7.

[4]. Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72.

[5]. Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649.