Disodium succinate | 丁二酸二钠

MCE 国际站：Disodium succinate

中文名：丁二酸二钠

CAS：150-90-3

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：琥珀酸二钠是琥珀酸的二钠盐。琥珀酸是三羧酸循环的中间产物，也是厌氧代谢的发酵产物之一^[1]。

体内：Succinic acid (3-6 mg/kg; 口服给药; 单剂量) 在小鼠中具有抗焦虑作用[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Elevated plus-maze test mice model[3] Dosage: 3 mg/kg, 6 mg/kg Administration: Oral gavage (p.o.); Single dose Result: At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed. Animal Model: Food intake mice model [3] Dosage: 3 mg/kg, 6 mg/kg, 12 mg/kg Administration: Intraperitoneal injection (i.p.); Single dose Result: Significantly increased the mice's food intake within 5 minutes after administration. Animal Model: Stress-induced hyperthermia test mice model[3] Dosage: 1.5 mg/kg, 3 mg/kg, 6 mg/kg Administration: Oral gavage (p.o.); Single dose Result: Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.

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研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

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参考文献：[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. 

[2]. Johns A T. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation[J]. The Biochemical journal, 1948, 42(1): ii.

[3]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. doi: 10.1016/j.lfs.2003.06.017. PMID: 14561530.

[4]. Xu J, et al. Microbial succinic acid, its polymer poly (butylene succinate), and applications[J]. Plastics from bacteria: Natural functions and applications, 2010: 347-388.

[5]. Bechthold I, et al. Succinic acid: a new platform chemical for biobased polymers from renewable resources[J]. Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment‐Process Engineering‐Biotechnology, 2008, 31(5): 647-654.