Fluridone | 氟啶酮

MCE 国际站：Fluridone

中文名：氟啶酮

CAS：59756-60-4

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：Fluridone 是脱落酸 (ABA) 生物合成的抑制剂。 Fluridone 抑制 AchnFAR 和 TF 基因的表达并减少伯醇的形成^[1]。

体外：Fluridone（0.5-50 μM；持续 4 天）抑制主动脉平滑肌细胞的增殖，并减少人活化淋巴细胞的增殖和细胞因子释放。在受刺激的人单核细胞中，Fluridone 抑制 COX-2 的表达以及 MCP-1 和前列腺素-E2 的释放。Fluridone 还可抑制受刺激的人类单核细胞释放脱落酸[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Fluridone（8.25 mg/kg；腹腔注射；一次）可减轻酵母聚糖治疗小鼠的腹膜炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD mice (20-22 g) treated with Zymosan[1] Dosage: 8.25 mg/kg Administration: i.p.; once Result: Reduced peritoneal inflammation in Zymosan-treated mice.

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研究领域：Others

作用靶点：Others

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参考文献：[1]. Wei X, et al. MYB41, MYB107, and MYC2 promote ABA-mediated primary fatty alcohol accumulation via activation of AchnFAR in wound suberization in kiwifruit. Hortic Res. 2020;7(1):86.

[2]. Mirko Magnone, et al. Fluridone as a new anti-inflammatory drug. Eur J Pharmacol. 2013 Nov 15;720(1-3):7-15.