Sodium nitroprusside | 硝普钠

MCE 国际站：Sodium nitroprusside

中文名：硝普钠

CAS：14402-89-2

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture and light

生物活性：硝普钠 (Ro 21-2498) 是一种有效的血管扩张剂，通过在血液中自发释放 NO 发挥作用。  

体外：Sodium nitroprusside (Ro 21-2498) 是一种有效的血管扩张剂。硝普钠在小动脉和小静脉中具有强效的血管扩张作用。硝普钠在循环中分解释放一氧化氮 (NO)。 NO 激活血管平滑肌中的鸟苷酸环化酶并增加细胞内 cGMP 的产生。最终结果是血管平滑肌松弛，从而使血管扩张 [1]。硝普钠可降低血管平滑肌细胞的增殖 [2]。硝普钠 (5 mg/kg) 作为一氧化氮供体可显着降低大鼠肠道缺血再灌注损伤 [3]。

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研究领域：Others

作用靶点：Others

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参考文献：[1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

[2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

[3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.