Ceftazidime | 头孢他啶

MCE 国际站：Ceftazidime

中文名：头孢他啶

CAS：72558-82-8

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：Ceftazidime (GR20263) 是一种抗生素，对革兰氏阳性和革兰氏阴性需氧菌具有广谱活性。 Ceftazidime 对肠杆菌科（包括 β-内酰胺酶阳性菌株）也有活性，并且对大多数 β-内酰胺酶^[1] 的水解具有抗性。  

体外：头孢他啶（约 0-8 µg/mL，24 小时）显示出针对 P 的抗菌和抗生物膜活性。铜绿假单胞菌菌株^[2].Ceftazidime (0-40 µg/mL approximately, 18-20 h)对S具有抑制活性。 maltophilia 分离^[3]。

体内：头孢他啶（注射 2 小时，2 000 毫克，每 8 小时一次，持续 24 小时）适度降低小鼠大腿感染模型中的细菌密度^[4]。

参考文献：[1]. Richards DM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29(2):105-61.

[2]. Esmat Kamali, et al. In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms. BMC Microbiol. 2021 Dec 16;21(1):347. 

[3]. Qiuxia Lin, et al. Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro. BMC Microbiol. 2021 Feb 22;21(1):60. 

[4]. Shawn H MacVane, et al. Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model. Antimicrob Agents Chemother. 2014 Nov;58(11):7007-9.