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MCE 国际站:Dexrazoxane
中文名:右雷佐生
CAS:24584-09-6
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Dexrazoxane (ICRF-187) 是一种心脏保护剂。目标:其他 右雷佐生是一种心脏保护剂。右雷佐生是 EDTA 的衍生物,右雷佐生螯合铁,从而减少与蒽环类化合物络合的金属离子的数量,从而减少超氧自由基的形成。确切的螯合机制尚不清楚,但据推测右雷佐生可在细胞内转化为开环形式并干扰铁介导的自由基生成,这在一定程度上被认为是蒽环类药物诱发的心肌病的原因。据推测,右雷佐生可用于进一步研究合成新的抗疟药[1, 2]。
热销产品:NVR 3-778 | AS 1411 | Animal-Free IL-2, Pig (His) | Sanguinarine (chloride) | Ravulizumab | Formamide | MZ 1 | Lusvertikimab | Thalidomide-NH-C5-NH2 (hydrochloride) | Ciprofloxacin
研究领域:Others
作用靶点:Others
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Jones, R.L., Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7.
[2]. Loyevsky, M., et al., Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol, 1999. 91(2): p. 105-14.
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