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2-Bromohexadecanoic acid | 2-溴十六烷酸
MCE 国际站:2-Bromohexadecanoic acid
中文名:2-溴十六烷酸
CAS:18263-25-7
品牌:MedChemExpress (MCE)
存储条件:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month生物活性:2-Bromohexadecanoic acid (2-Bromopalmitic acid) 是一种 2-溴棕榈酸,可转化为 2-bromopalmitate (2-BP)。2-BP 是一种棕榈酰化抑制剂,靶向 DHHC (Asp-His-His-Cys) 蛋白棕榈酰转移酶。2-BP 抑制 GSDME-C 的棕榈酰化,抑制 BAK/BAX-Caspase 3-GSDME 通路介导的焦亡 (pyroptosis)。
体外:棕榈酰化促进 GSDME-N 在切割后释放 GSDME-C,2-BP 抑制棕榈酰化过程,而抑制 GSDME-C 的修饰,增加了 GSDME-C 和 GSDME-N 之间的相互作用。2-BP 抑制 TNFa+CHX 诱导的细胞凋亡,但不抑制细胞总死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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研究领域:Apoptosis | Immunology/Inflammation
作用靶点:Pyroptosis
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参考文献:[1]. Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11(4):281.
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