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MCE 国际站:Polyphyllin VI
中文名:重楼皂苷VI
CAS:55916-51-3
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Polyphyllin VI 是一种活性皂苷,具有抗癌活性。 Polyphyllin VI 诱导 G2/M 细胞周期停滞并触发细胞凋亡[1][2]。 Polyphyllin VI 在非小细胞肺癌中通过诱导 ROS/NF-κB/NLRP3/GSDMD 信号轴诱导 caspase-1 介导的细胞焦亡[3]。
体外:Polyphyllin VI (0-16 μM;48 小时) 以剂量依赖性方式显着降低 A549、NCI-H1299 和 HepaRG 细胞的活力[1][2]。 Polyphyllin VI (0.5-2 μM-1 μM;24 小时) 以剂量依赖性方式显着增加 A549 和 NCI-H1299 细胞处于 G2/M 期的百分比[1]。 Polyphyllin VI (0-12 μM-1 μM;24 小时) 将 HepaRG 细胞阻滞于 S 期[2]。 Polyphyllin VI (0-6 μM-1 μM;24 小时) 可激活 NLRP3 炎症小体[3]。 Polyphyllin VI (0-6 μM-1 μM;24 小时) 通过 ROS/NF-κB 途径诱导 A549 和 NCI-H1299 细胞焦亡 (pyroptosis)[3] 。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Polyphyllin VI (2-4 mg/kg;腹腔注射;每周 5 次,持续 4 周) 抑制肺癌肿瘤异种移植物的生长[1]。 Polyphyllin VI (2.5-10 mg/kg;腹腔注射;连续 10 天) 在携带 A549 肿瘤的裸鼠中激活 NLRP3 炎性小体[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[1] Dosage: 2 mg/kg, 3 mg/kg, 4 mg/kg Administration: Intraperitoneal Injection (i.p.) Result: Resulted the reduction of tumor volume to 25.63%, 41.71%, and 40.41%, respectively, after 2 mg/kg, 3 mg/kg and 4 mg/kg treatment. Animal Model: A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[3] Dosage: 2.5 mg/kg, 5 mg/kg, 10 mg/kg Administration: Intraperitoneal Injection (i.p.) Result: Showed the expression of NLRP3, caspase-1, IL-1β and GSDMD was increasing in a dose manner.
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研究领域:Apoptosis | Immunology/Inflammation
作用靶点:Apoptosis | Pyroptosis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct;29(10):1568-76.
[2]. Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15;10(5). pii: E201.
[3]. Jin-Feng Teng, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Jan 13;12(1):193.
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