L-Glutamic acid

详情：L-Glutamic acid

中文名：L-谷氨酸

CAS：56-86-0

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：L-谷氨酸作为一种兴奋性递质和所有亚型谷氨酸受体（代谢型、红藻氨酸、NMDA 和 AMPA）的激动剂。 L-Glutamic acid 显示出对多巴胺能末端释放 DA 的直接激活作用。 IC50 和目标：DA^[1]。 

体外：L-Glutamic acid 可通过突触前谷氨酸能受体作用于 [³H]DA 释放。在河豚毒素 (0.5 μM)^[1] 存在的情况下，L-谷氨酸 (50 μM) 仍能刺激 [³H] DA 的释放。

体内：L-Glutamic acid (3 g/kg, 皮下注射) 在小鼠中可促进视网膜神经节细胞的兴奋毒性变性[1]。 L-Glutamic acid (750 mg/kg, 腹腔注射) 在大鼠中可以减轻和抑制有机磷杀虫剂毒死蜱 (CPF) 诱导的氧化应激反应[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Crv4 mice model[1] Dosage: 3 g/kg Administration: s.c., single dose Result: Reduced the number of Brn-3a+ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished. Animal Model: CPF-induced rat model[5] Dosage: 750 mg/kg Administration: i.p. Result: Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.

参考文献：[1]. Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149.[2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.[3]. Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132.[4]. Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30.[5]. Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163.