reductive monocarboxylic acid cycle

 

  

The reduction of CO₂ to one-carbon units is essential for the anabolism of Clostridia. In the case of Clostridium kluyveri , CO₂ was shown to be the predominant precursor of one-carbon units [ Decker67 , Jungermann68 ]. The process is mediated by two key enzymes. The indirect CO₂ reduction via reductive carboxylation of acetyl-CoA to pyruvate is catalyzed by the enzyme pyruvate synthase . The pyruvate is cleaved into acetyl-CoA and formate by the enzyme pyruvate formate-lyase . The formate thus formed enters the anabolic pathways by incorporation into the one-carbon carrier tetrahydrofolate , generating N¹⁰-formyl-THF , a reaction catalyzed by formyltetrahydrofolate synthetase [ Thauer70 , Thauer72 ].

It should be noted that while in this pathway pyruvate formate-lyase provides an anabolic function, in other organisms, such as Escherichia coli K-12 , the enzyme has a pure catabolic function in the fermentation of pyruvate to acetate (see pyruvate fermentation to acetate IV ).

以上来自：biocyc.org, 更细节的材料见：http://biocyc.org/META/new-image?type=PATHWAY&object=PWY-5493

原始的文献：

1970年发表的文献：

The synthesis of one-carbon units from CO2 via a new ferredoxin dependent monocarboxylic acid cycle.pdf

转载本文请联系原作者获取授权，同时请注明本文来自陈文峰科学网博客。
链接地址：https://blog.sciencenet.cn/blog-3533-9993.html

上一篇：二氧化碳的固定：厌氧的乙酰辅酶A途径
下一篇：乙醛酸循环-glyoxylate cycle