3-Methyl-2-oxobutanoic acid

MCE 国际站：3-Methyl-2-oxobutanoic acid

CAS：759-05-7

品牌：MedChemExpress (MCE)

存储条件：Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：3-Methyl-2-oxobutanoic acid 是 Escherichia coli 中泛酸的前体。 

体外：3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) 是 Escherichia coli^[1] 中泛酸的前体。 3-甲基-2-氧代丁酸（α-酮异戊酸）增强α-酮异己酸和α-酮-β-甲基-正戊酸，但减少相应的氨基酸，并导致鸟氨酸的早期下降以及血浆精氨酸的晚期增加^[2]。

体内：3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) 通过 GABAergic 和 glutamatergic 机制诱导大鼠惊厥^[3]。

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研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

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参考文献：[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.