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MCE 国际站:Tafasitamab
CAS:1422527-84-1
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体,可结合人 B 细胞表面抗原CD19[1][2]。
体外:Tafasitamab (XmAb5574) 以 E/T 比率依赖性方式诱导对 Mino 和 Jeko (MCL) 细胞系的细胞毒性。 Tafasitamab (XmAb5574) 增加 ADCP 和抗增殖活性。 Tafasitamab (XmAb5574) 可增强半胱天冬酶诱导细胞凋亡引起的抗增殖细胞凋亡活性[1][2]。
体内:Tafasitamab(SC,第 1 天一次,2.5 μg/kg)抑制播散性 BL 小鼠异种移植肿瘤模型中的淋巴瘤生长[1]。
热销产品:Trachelogenin | Rabeprazole (sodium) | Atenolol | Selonsertib | Butylphthalide | Rhein | Se-Methylselenocysteine | Bilirubin | Salmeterol | MRT67307
研究领域:Apoptosis
作用靶点:Apoptosis
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Jung Hyun Her, et al. Tafasitamab mediates killing of B-cell non-Hodgkin's lymphoma in combination with γδ T cell or allogeneic NK cell therapy. Cancer Immunol Immunother. 2022 Mar 29.
[2]. Holly M Horton, et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res
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