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Vilazodone (Hydrochloride) | 盐酸维拉佐酮
MCE 国际站:Vilazodone (Hydrochloride)
中文名:盐酸维拉佐酮
CAS:163521-08-2
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是一种5-羟色胺转运蛋白 (SER) 抑制剂和 5-HT1A 受体部分激动剂。 IC50 和目标:SER; 5-HT1A[1]。
体内:施用 5-HT1A 受体激动剂会产生一种特征性的行为综合征,包括姿势改变、后肢减少、头部摆动、震颤、前爪踩踏和 straub 尾巴。在大鼠超声波发声试验中,应激诱导的发声在给药后 120 分钟和 210 分钟被 Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) 抑制。 Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip),急性或预防性给药(行为测试前 1 周),减弱的应激诱导增强的惊吓,但对高架十字迷宫中的应激增强的焦虑反应没有影响。有趣的是,较低剂量的 10 mg/kg 盐酸维拉佐酮(EMD 68843 盐酸盐)在惊吓反应中具有相反的效果,表明存在某种无法解释的双向效应,并且所有剂量都会增强惊吓诱导的应激反应,可能提示类似焦虑的反应[1]。 Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 也是治疗 MDD[2] 的另一种选择。
热销产品:Captopril | NSC319726 | Zileuton | Glucoraphanin | Itaconic acid | Nifedipine | PHTPP | Bexarotene | Ursolic acid | Bobcat339 (hydrochloride)
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:5-HT Receptor | Serotonin Transporter
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:[1]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009
[2]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28(1):27-39.
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