Calycosin-7-O-β-D-glucoside | 毛蕊异黄酮苷

MCE 国际站：Calycosin-7-O-β-D-glucoside

中文名：毛蕊异黄酮苷

CAS：20633-67-4

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Calycosin-7-O-β-D-glucoside 是一种从 Astragali Radix 中分离得到的异黄酮。 Calycosin-7-O-β-D-glucoside 具有神经保护、心脏保护、抗炎、抗氧化应激等多种生物学活性^[1][2]。  

体外：Calycosin-7-O-β-D-glucoside（2 μM；6 小时）显着抑制 MMP 的表达和活性，并确保 cav-1 和紧密连接蛋白在从缺血大鼠皮层分离的微血管中表达 ^[1]。

体内：Calycosin-7-O-β-D-glucoside（腹腔注射；26.8 mg/kg；14 天）在体内 MCAO 缺血再灌注大鼠模型中显着减少梗死体积、组织学损伤和 BBB 通透性^{[1]< /sup>。}

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研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

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参考文献：[1]. Shuping Fu, et al. Calycosin-7-O-β-D-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2014 Aug 8;155(1):692-701.

[2]. Xiangli Yan, et al. Calycosin-7- O- β- D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1 α Pathway in HT22 Cells. Neural Plast. 2019 Dec 1;2019:8798069.