Desloratadine | 地氯雷他定

MCE 国际站：Desloratadine

中文名：地氯雷他定

CAS：100643-71-8

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Desloratadine (Sch34117) 是具有口服活性的非镇静剂 H1-抗组胺药 Loratadine 的主要代谢物。 Desloratadine 是一种选择性 H1 受体 拮抗剂，具有抗过敏和抗炎作用^[1][2]。

热销产品：CCT241533 (hydrochloride)  | Diphenhydramine (hydrochloride)  | Co(III) protoporphyrin IX chloride  | Aripiprazole  | SRT 1460  | Cilazapril (monohydrate)  | Amiodarone (hydrochloride)  | Mupadolimab  | Uridine 5'-monophosphate  | Chlortetracycline (hydrochloride)

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：Histamine Receptor  |  Endogenous Metabolite

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.

[2]. Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.

[3]. Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.

[4]. McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.