Polymyxin B | 多黏菌素 B

MCE 国际站：Polymyxin B

中文名：多黏菌素 B

CAS：1404-26-8

品牌：MedChemExpress (MCE)

存储条件：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

生物活性：Polymyxin B 是一种抗生素 (antibiotic)。Polymyxin B 通过与细菌 (bacterial) 壁的 LPS 高亲和力结合去抑制革兰氏阴性菌 (Gram-negative) 感染。Polymyxin B 可以中和内毒素的效果。Polymyxin B 通过增加其渗透性诱导细菌死亡。Polymyxin B 可用于内毒素血症研究。

体外：Polymyxin B (10 μg/mL，6 小时) 降低了人外周血单核细胞 (PBMC) 中的 TNF-α 和 IL-10 的产生[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Polymyxin B (5-20 mg/kg，静脉注射；每日 1 次，连续 7 天) 在 20 mg/kg 的浓度下到达 Sprague-Dawley 大鼠模型的肾毒性终点，在 5 mg/kg 的浓度下没有[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

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参考文献：[1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.

[2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16.

 [3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.